AntidepressantsClassification1. Reversible inhibitors of MAO-A (RIMAs) Moclobemide, clorgyline 2. Tricyclic antidepressants (TCAs) NA + 5-HT reuptake inhibitors: Imipramine, Amitriptylline, Trimipramine, Doxepin, Dothiepin, ClomipraminePredominantly NA reuptake inhibitors: Desipramine, Nortriptylline, Amoxapine, Reboxetine 3. Selective serotonin reuptake inhibitors (SSRIs) Fluoxetine, fluvoxamine, Paroxetine, Sertraline,...

Potassium channel openers Include: MinoxidilDiazoxideNicornadilPinacidilCromakalim The chemical and electrical gradients for K+ across the plasma membrane are in opposite direction. As such, depending on the channel, this ion can move in either direction. Such movement is regulated by multiple types of...

Antihypertensives Anti hypertensive drugs Most cases of hypertension are idiopathic, also called “primary’’ or “essential” hypertension. The strategies for treating it are based on the determinants of arterial pressure. These include reductions of blood volume, sympathetic effects, vascular smooth muscle tension...

Calcium channel blockers Classification Verapamil – a phenyl alkylamine, hydrophilic papaverine derivativeNifedipine – a dihydropyridine (lipophillic)Diltiazem -  hydrophilic benzothiazepine  The dihydropyridines (DHPs) are the most potent Ca2+ channel blockers. Voltage sensitive calcium channels    L type (long lasting current) T type...

Antianginal drugs Classification  1.       Nitrates a.       Short acting : Glyceryl trinitrate (GTN, Nitroglycerine) b.      Long acting: Isosorbide dintrate (short acting by sublingual nitrate), Isosorbide mononitrate, Erythrityl tetranitrate, Pentaerythritol tetranitrate 2.       β blockers: Propanolol, Metoprolol, Atenolol and others 3.       calcium channel...